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Mapping of centrifugal inputs onto newborn neurons in the adult mouse olfactory bulb

Research Project

Project/Area Number 25830032
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionThe University of Tokyo

Principal Investigator

MURATA Koshi  東京大学, 医学(系)研究科(研究院), 特任助教 (10631913)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経科学 / 成体ニューロン新生 / 嗅球 / 嗅結節 / 逆行性トレーシング / 嗅皮質 / 成体神経新生 / 嗅覚学習
Outline of Final Research Achievements

The olfactory bulb is the first relay of olfaction in the central nervous system, and unique in that new neurons are continuously generated and incorporated into the preexisting neuronal circuit throughout life. Newborn neurons in the adult mouse olfactory bulb are suggested to play a role in formation of olfactory memories. Although the incorporation of newborn neurons into the preexisting neuronal circuit is regulated by, at least in part, the centrifugal inputs from the wide areas of the olfactory cortex, the anatomical connection between newborn neurons and neurons in the olfactory cortex is unclear. In this study, I performed retrograde transsynaptic tracing using modified-rabies virus and revealed distribution of the presynaptic neurons in the olfactory cortex onto newborn neurons in the olfactory bulb.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Reorganization of neuronal circuits of the central olfactory system during postprandial sleep2013

    • Author(s)
      Yamaguchi M, Manabe H, Murata K, and Mori K
    • Journal Title

      Frontiers in neural Circuits

      Volume: 7 Pages: 132-132

    • DOI

      10.3389/fncir.2013.00132

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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