| Project/Area Number |
25830032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MURATA Koshi 東京大学, 医学(系)研究科(研究院), 特任助教 (10631913)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経科学 / 成体ニューロン新生 / 嗅球 / 嗅結節 / 逆行性トレーシング / 嗅皮質 / 成体神経新生 / 嗅覚学習 |
|---|
| Outline of Final Research Achievements |
The olfactory bulb is the first relay of olfaction in the central nervous system, and unique in that new neurons are continuously generated and incorporated into the preexisting neuronal circuit throughout life. Newborn neurons in the adult mouse olfactory bulb are suggested to play a role in formation of olfactory memories. Although the incorporation of newborn neurons into the preexisting neuronal circuit is regulated by, at least in part, the centrifugal inputs from the wide areas of the olfactory cortex, the anatomical connection between newborn neurons and neurons in the olfactory cortex is unclear. In this study, I performed retrograde transsynaptic tracing using modified-rabies virus and revealed distribution of the presynaptic neurons in the olfactory cortex onto newborn neurons in the olfactory bulb.
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