| Project/Area Number |
25830035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
Jun Yamada 九州大学, 医学(系)研究科(研究院), 助教 (70582708)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 海馬 / GABAニューロン / ペリニューロナルネット / パルブアルブミン / WFAレクチン / コンドロイチナーゼABC |
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| Outline of Final Research Achievements |
The perineuronal nets (PNNs) surround the soma of a subset of neurons, and is considered to play a critical role in regulation of neural plasticity. Seminal works using immuno/lectin histochemistry reported that PNNs were associated with parvalbumin-expressing (PV+) GABAergic neurons. Although later reports have shown that PV+ neurons consist of at least five subclasses (basket cells, axo-axonic cells, bistratified cells, oriens-lacunosum-moleculare (O-LM) cells and hippocampo-septal projection (H-S) cells), the relationship between PNNs and classification of PV+ neurons remains unclear. We clarify whether PNNs are associated with specific subclasses of PV+ neurons in the mouse hippocampus. The vast majority of PV+ basket cells were surrounded by PNNs, while only a minor population of PV+ axo-axonic, O-LM, and H-S cells were enwrapped with PNNs. These data provide evidence that PNNs may critically regulate hippocampal neuronal activity via subclass specific expression in PV+ neurons.
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