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Subclass-specific expression of perineuronal nets in parvalbumin-containing GABAergic neurons in the mouse hippocampus

Research Project

Project/Area Number 25830035
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyushu University

Principal Investigator

Jun Yamada  九州大学, 医学(系)研究科(研究院), 助教 (70582708)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords海馬 / GABAニューロン / ペリニューロナルネット / パルブアルブミン / WFAレクチン / コンドロイチナーゼABC
Outline of Final Research Achievements

The perineuronal nets (PNNs) surround the soma of a subset of neurons, and is considered to play a critical role in regulation of neural plasticity. Seminal works using immuno/lectin histochemistry reported that PNNs were associated with parvalbumin-expressing (PV+) GABAergic neurons. Although later reports have shown that PV+ neurons consist of at least five subclasses (basket cells, axo-axonic cells, bistratified cells, oriens-lacunosum-moleculare (O-LM) cells and hippocampo-septal projection (H-S) cells), the relationship between PNNs and classification of PV+ neurons remains unclear. We clarify whether PNNs are associated with specific subclasses of PV+ neurons in the mouse hippocampus. The vast majority of PV+ basket cells were surrounded by PNNs, while only a minor population of PV+ axo-axonic, O-LM, and H-S cells were enwrapped with PNNs. These data provide evidence that PNNs may critically regulate hippocampal neuronal activity via subclass specific expression in PV+ neurons.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Comparative morphometric analysis of microglia in the spinal cord of SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.2016

    • Author(s)
      Ohgomori T, Yamada J, Takeuchi H, Kadomatsu K, Jinno S.
    • Journal Title

      Eur J Neurosci

      Volume: in press Issue: 10 Pages: 1340-1351

    • DOI

      10.1111/ejn.13227

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Subclass-specific formation of perineuronal nets around parvalbumin-expressing GABAergic neurons in the Ammon’s horn of the mouse hippocampus.2015

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      J Comp Neurol

      Volume: 523 Issue: 5 Pages: 790-804

    • DOI

      10.1002/cne.23712

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perineuronal nets affect parvalbumin expression in GABAergic neurons of the mouse hippocampus.2014

    • Author(s)
      Yamada J, Ohgomori T, Jinno S.
    • Journal Title

      Eur J Neurosci

      Volume: 41 Issue: 3 Pages: 368-378

    • DOI

      10.1111/ejn.12792

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] S100A6 (calcyclin) is a novel marker of neural stem cells and astrocyte precursors in the subgranular zone of the adult mouse hippocampus.2014

    • Author(s)
      Yamada J, Jinno S.
    • Journal Title

      Hippocampus

      Volume: 24 Issue: 1 Pages: 89-101

    • DOI

      10.1002/hipo.22207

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spatio-temporal differences in perineuronal net expression in the mouse hippocampus, with reference to parvalbumin2013

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      Neurosci

      Volume: 253 Pages: 368-79

    • DOI

      10.1016/j.neuroscience.2013.08.061

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis2013

    • Author(s)
      Yamada J, Jinno S
    • Journal Title

      J Comp Neurol

      Volume: 521 Issue: 5 Pages: 1184-201

    • DOI

      10.1002/cne.23228

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Alterations in aggrecan expression in the mouse hippocampus by aging and memantine2016

    • Author(s)
      山田純、神野尚三
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペリニューロナルネットによる海馬神経回路の制御2016

    • Author(s)
      山田純、神野尚三
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレット福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 加齢に伴うアグリカンコアタンパク質とCat-315糖鎖の発現変動とメマンチンによる制御2015

    • Author(s)
      山田純、大篭友博、神野尚三
    • Organizer
      第71回日本解剖学会九州支部学術集会
    • Place of Presentation
      熊本大学
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Versican-immunoreactive perineuronal nets may be formed around ivy cells or neurogliaform cells in the hippocampus.2015

    • Author(s)
      山田純、神野尚三
    • Organizer
      第38回日本神経科学大会(Neuro2015)
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subclass-specific expression of perineuronal nets around parvalbumin-expressing GABAergic neurons in the mouse hippocampus.2015

    • Author(s)
      Jun Yamada
    • Organizer
      第120回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Molecular heterogeneity of perineuronal nets and regulation of neuronal circuits in the hippocampus2014

    • Author(s)
      Jun Yamada, Shozo Jinno
    • Organizer
      第37回日本神経科学大会(Neuro2014)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] ペリニューロナルネットはPV陽性GABAニューロンのサブクラス特異的に発現している2014

    • Author(s)
      山田純、神野尚三
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Perineuronal nets restrict synaptic plasticity in the CA2 region of the mouse hippocampus2013

    • Author(s)
      Jun Yamada, Shozo Jinno
    • Organizer
      第36回日本神経科学大会 (Neuro2013)
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] 加齢によるオリゴデンドロサイト前駆細胞とオリゴデンドロサイトのホメオスタシスの変化2013

    • Author(s)
      山田純、神野尚三
    • Organizer
      包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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