| Project/Area Number |
25830039
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Shinshu University |
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Principal Investigator |
SUZUKI Emi 信州大学, 医学部, 研究員 (80623686)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | aipha synuclein / Parkinson disease / alimentary tract / α-synuclein / パーキンソン病 / リンパ組織 / α-Synuclein |
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| Outline of Final Research Achievements |
Cells containing phosphorylated (p-) alphasynuclein aggregation were examined immunohistochemically in brains, alimentary tracts and cervical lymphnodes of patients with 21 Parkinson disease (PD) and neurologically free 11 control subjects and of 8 alphasynuclein Tg mice. The present study elucidated that 1. aggregation of p-alphasynuclein occurred in the peripheral nervous system in the alimentary tract of patients who don’t develop PD, 2. number of cells immunopositive for p-alphasynuclein, which are considered to be macrophages, in the cervical lymphnodes was larger than that of controls, 3. number of cells immunopositive for p-alphasynuclein in the lymphoid tissue of the alphasynuclein Tg mice showed no difference from that of the wild type mice.
These findings indicate that the lymphatic tissue may play a role in initiation and progression in aggregation of p-alphasynuclein in PD.
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