| Project/Area Number |
25830041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Doshisha University |
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Principal Investigator |
URANO Yasuomi 同志社大学, 生命医科学部, 助教 (00546674)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経変性疾患 / アルツハイマー病 / 細胞内輸送 / クルクミン / 脂質代謝 / 酸化ステロール |
|---|
| Outline of Final Research Achievements |
A major pathological hallmark of Alzheimer’s disease is the accumulation of Amyloid β (Aβ) in senile plaques. Aβ is generated from Amyloid precursor protein (APP) by cleavage with secretases. In this study, I found that the treatment with 24S-hydroxycholesterol, which is the brain-specific oxysterol, inhibited Aβ production by suppression of intracellular transport of APP from the endoplasmic reticulum to the Golgi.
I also conducted in vitro screening of curcumin derivatives. I identified compound which inhibited Aβ production without affecting secretase activities via suppression of intracellular APP trafficking.
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