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Adiponectin, anti diabetic adipokine, as a novel therapeutic strategy for synucleinopathies.

Research Project

Project/Area Number 25830044
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

SEKIYAMA Kazunari  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 (40572764)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経変性疾患 / シヌクレイノパチー / アディポネクチン / α-シヌクレイン / トランスジェニックマウス / シヌクレイン / 神経変性
Outline of Final Research Achievements

The main objective of this study was to determine whether adiponectin (APN), a adipokine with anti-diabetic and anti-atherosclerosis properties, may protect against α-synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). First, APN was protective in vitro; aggregation of α-synuclein (αS) in B103 neuroblastoma cells expressing αS, was significantly ameliorated by treatment with recombinant APN. Second, various neuropathological features in αS transgenic mice, including αS aggregation and movement disorder, were significantly ameliorated by nasal treatment of the mice with APN. Our results suggest that APN may act as anti-neuropathogenic in the pathogenesis of α-synucleinopathies and that APN signaling pathway might be a therapeutic target of α-synucleinopathies.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Insight into the dissociation of behavior from histology in Synucleinopathies and in related neurodegenerative diseases2016

    • Author(s)
      Sekiyama K, Takamatsu Y, Koike W, Waragai M, Takenouchi T, Sugama S, Hashimoto M.
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: in press Issue: 3 Pages: 831-841

    • DOI

      10.3233/jad-151015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] シヌクレイントランスジェニックマウス2015

    • Author(s)
      関山一成, 橋本 款.
    • Journal Title

      細胞

      Volume: Vol.47 No.1 Pages: 16-19

    • Related Report
      2014 Research-status Report
  • [Journal Article] Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathie2014

    • Author(s)
      Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada A, Masliah E, Hashimoto M
    • Journal Title

      Ann Clin Transl Neurol

      Volume: 1 Issue: 7 Pages: 479-489

    • DOI

      10.1002/acn3.77

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of genomics in translational research for Parkinson's disease.2014

    • Author(s)
      Sekiyama K, Takamatsu Y, Waragai M, Hashimoto M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 452(2) Pages: 226-235

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dual effects of βsynuclein in the pathogenesis of Parkinson's disease2013

    • Author(s)
      Akio Sekigawa, Kazunari Sekiyama, Masayo Fujita, Yoshiki Takamatsu, Albert R. La Spada, Elizer Masliah, Makoto Hashimoto
    • Journal Title

      Annals of Neurology

      Volume: 7 Issue: 2 Pages: 306-306

    • DOI

      10.1002/ana.23936

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies2013

    • Author(s)
      Sekigawa A
    • Journal Title

      Oxid Med Cell Longev.

      Volume: 2013 Pages: 817807-817807

    • DOI

      10.1155/2013/817807

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biomarkers for the diagnosis and management of Parkinson’s disease.2013

    • Author(s)
      Waragai M, Sekiyama K, Fujita M, Tokuda T, *Hashimoto M.
    • Journal Title

      Exp. Opi. Med. Diag.

      Volume: 1 Pages: 71-83

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of APPL-1, in adiponectin/insulin-mediated protection against neurodegeneration in a cellular model of α-synucleinopathies.2015

    • Author(s)
      Kazunari Sekiyama, Waragai Masaaki, Yoshiki Takamatsu, Makoto Hashimoto.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸ポートアイランド 兵庫県神戸市
    • Year and Date
      2015-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Adiponectin, the anti-diabetic adipokine, has a therapeutic effect in models of α-synucleinopathies.2015

    • Author(s)
      Sekiyama K, Waragai M, Takamatsu Y, Hashimoto M.
    • Organizer
      ADPD 2015
    • Place of Presentation
      フランス、ニース、アクロポリス国際会議場
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] アディポネクチンはα-シヌクレイノパチー細胞モデルのインスリンシグナルを亢進し神経変性の病態を改善する。2014

    • Author(s)
      関山 一成,高松 芳樹,橋本 款
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 神奈川県横浜市
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] レビー小体型認知症で見出された変異型βシヌクレインを発現するショウジョウバエは神経変性様表現型を示す。2014

    • Author(s)
      高松 芳樹、関山 一成、本多 芳子、児玉 亨、橋本 款
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 神奈川県横浜市
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] The anti-diabetic hormone, adiponectin, has protective effect on the pathogenesis of in vitro and in vivo models of α-synucleinopathies.

    • Author(s)
      Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M
    • Organizer
      Neuroscinence 2013
    • Place of Presentation
      San Diego, 米国
    • Related Report
      2013 Research-status Report
  • [Presentation] シヌクレイノパチー病態におけるアディポネクチンの治療効果について.

    • Author(s)
      関山 一成, 藤田 雅代, 高松 芳樹, 橋本 款.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Research-status Report
  • [Presentation] レビー小体型認知症で同定された変異型β シヌクレイン(P123H, V70M) を導入したショウジョウバエの解析.

    • Author(s)
      高松 芳樹,関川 明生,堀内 純二郎,関山 一成,藤田 雅代,児玉 亨,齋藤 実,橋本 款.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Research-status Report
  • [Book] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging.2014

    • Author(s)
      Takenouchi T, Sekiyama K Tsukimoto M, Iwamaru Y, Takato Takenouchi, Kazunari Sekiyama, Fujita M, Sugama S, Kitani H, Hashimoto M.
    • Total Pages
      304
    • Publisher
      Elsevier Science
    • Related Report
      2014 Research-status Report
  • [Remarks] 公益財団法人 東京都医学総合研究所 パーキンソン病研究室

    • URL

      http://www.igakuken.or.jp/parkinson/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 公益財団法人東京都医学総合研究所パーキンソン病プロジェクト

    • URL

      http://www.igakuken.or.jp/parkinson/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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