The role of alpha2-antiplasmin in memory formation and dendritic growth

• Project/Area Number: 25830057
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Doshisha Women's College of Liberal Arts
• Principal Investigator: KAWASHITA Eri 同志社女子大学, 薬学部, 助教 (80509266)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: α2-antiplasmin / 記憶 / 樹状突起 / 神経細胞 / α2アンチプラスミン / 線維素溶解系因子

Outline of Final Research Achievements

We found that α2-Antiplasmin (α2AP) is a crucial mediator of cognitive function. We also demonstrated that α2AP induces dendritic growth in hippocampal neurons through p38 MAPK activation, independent of plasmin.

Research Products

• [Journal Article] Altered behavior in mice with deletion of the alpha2-antiplasmin gene. (2014)
  • Author(s): Kawashita E, Kanno Y, Ikeda K, Kuretake H, Matsuo O, Matsuno H.
  • Journal Title: PLoS One. Volume: 9 (5) Issue: 5 Pages: e97947-e97947
  • DOI: 10.1371/journal.pone.0097947
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered behavior in mice with deletion of the alpha2-antiplasmin gene (2014)
  • Author(s): Kawashita E, Kanno Y, Ikeda K, Kuretake H, Matsuo O, Matsuno H
  • Journal Title: PLoS One. Volume: in press
  • Peer Reviewed
• [Journal Article] 27. Involvement of alpha2-antiplasmin in dendritic growth in hippocampal neurons (2013)
  • Author(s): Eri Kawashita, Yosuke Kanno, Haruka Asayama, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno
  • Journal Title: Journal of Neurochemistry Volume: 126 Issue: 1 Pages: 58-69
  • DOI: 10.1111/jnc.12281
  • Peer Reviewed
• [Presentation] 脳老化におけるα2-antiplasmin及びplasminogen/plasminの関与 (2015)
  • Author(s): 池田夏菜子、河下映里、菅野陽介、呉竹宏美、土田佳穂、松尾理
  • Organizer: 日本薬学会 第135年会
  • Place of Presentation: 兵庫医療大学、神戸
  • Year and Date: 2015-03-27
• [Presentation] α2-antiplasminの記憶形成及び加齢性認知症への関与 (2014)
  • Author(s): 池田夏菜子、菅野陽介、呉竹宏美、河下映里
  • Organizer: 第64回日本薬学会近畿支部総会・大会
  • Place of Presentation: 京都薬科大学、京都
  • Year and Date: 2014-10-11
• [Presentation] 中枢神経機能におけるα2-antiplasminの役割 (2014)
  • Author(s): 河下映里
  • Organizer: 生体機能と創薬シンポジウム
  • Place of Presentation: 近畿大学、大阪
  • Year and Date: 2014-08-29
  • Invited
• [Presentation] α2-antiplasmin is a potential regulator of neuronal morphology (2013)
  • Author(s): Kawashita E
  • Organizer: XXIV ISTH Congress with 59th Annual SSC Meeting
  • Place of Presentation: Amsterdam, The Netherlands