| Project/Area Number |
25830072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
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| Keywords | 膵癌 / 動物モデル / BMP / BMPシグナル / 腫瘍間質相互作用 |
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| Outline of Final Research Achievements |
TGF-beta signaling has a crucial role in pancreatic tumorigenesis and progression, and almost all of pancreatic cancers carry at least one genetic alteration of TGF-beta related genes. However, the role of BMP signaling in pancreatic cancer remains unclear. We examined the effect of BMP signaling on the tumorigenesis of PDAC using mouse model.
The immunohistochemistry of murine pancreas tissues demonstrated BMP signaling was activated in ADM and PanIN lesions and more strongly phosphorylated in PDAC lesion. In ADM assay, Bmp4 and Bmp7 increased the ADM and Tgf beta decreased the ADM. Further, the deletion of Tgfbr2 increased ADM formation and DMH1, BMPR inhibitor decreased the ADM. These results suggest that BMP signaling plays an important role on the initiation of pancreatic cancer.
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