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A treatment strategy to target mitochondria-specific Hsp90 chaperones

Research Project

Project/Area Number 25830075
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YOSHIDA Soichiro  東京医科歯科大学, 医学部附属病院, 助教 (80383280)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords尿路上皮癌 / 分子シャペロン / ミトコンドリア / TRAP1
Outline of Final Research Achievements

TRAP1, a homologue of HSP90, are abundantly expressed in mitochondria.
We investigated the biological and prognostic role of TRAP1 expression in upper urinary tract urothelial carcinoma (UTUC). In 5637 cells, knockdown of endogenous TRAP1 potentiated cell invasiveness, which is attenuated by a ROS inhibitor. In addition, exogenous expression of TRAP1 hampered in vitro invasion of 5637 cells. We further evaluated TRAP1 expression in UTUC surgical specimens and its association with cancer-specific survival (CSS). Lower TRAP1 expression was an independent predictor of shorter CSS, along with histological grade and lymph node involvement. The 5-year CSS rates were 52% for patients with lower TRAP1 expression compared to 95% for those with higher TRAP1 expression. Taken together, impaired TRAP1 expression is associated with increased invasive potential via modulating ROS and unfavorable prognosis in UTUC.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results)

  • [Journal Article] Diffusion-weighted magnetic resonance imaging in management of bladder cancer, particularly with multimodal bladder-sparing strategy.2014

    • Author(s)
      Yoshida S, Koga F, Kobayashi S, Tanaka H, Satoh S, Fujii Y, Kihara K.
    • Journal Title

      World J Radiol.

      Volume: 6 Issue: 6 Pages: 344-354

    • DOI

      10.4329/wjr.v6.i6.344

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of diffusion-weighted magnetic resonance imaging as an imaging biomarker of urothelial carcinoma.2014

    • Author(s)
      Yoshida S, Koga F, Masuda H, Fujii Y, Kihara K.
    • Journal Title

      Int J Urol.

      Volume: 21 Issue: 12 Pages: 1190-1200

    • DOI

      10.1111/iju.12587

    • Related Report
      2014 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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