Research Project
Grant-in-Aid for Young Scientists (B)
Recent advances in cancer metabolism have revealed that metabolic abnormalities in cancer cells are closely related to enhanced cell proliferation and malignant progression of a number of tumors.Mutations in Retinoblastoma (RB) gene are found at the initiation of limited human cancers, whereas RB protein inactivation is frequently found in much wider variety of cancers mainly during their progression. These findings suggest that RB exerts more roles than previously thought. Here we show that RB affects transcription of many enzymes involved in Mevalonate (MVA) pathway. We demonstrate that RB depletion in prostate cancer cells induces some of typical malignant features including tumor sphere forming-activity and hormone-refractory growth. Cholesterol and its derivatives generated by MVA pathway contribute to these phenotypes through modifying cellular ROS level.These results indicate that RB regulates cancer progression through the metabolic function in controlling MVA pathway.
All 2015 2014 2013 Other
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Acknowledgement Compliant: 1 results) Presentation (19 results) Remarks (1 results)
STEM CELLS
Volume: - Issue: 5 Pages: 1657-1669
10.1002/stem.1971
Molecular and Cellular Biology
Volume: 33 Issue: 16 Pages: 3113-3124
10.1128/mcb.01597-12
120005312327
http://omb.w3.kanazawa-u.ac.jp/
