Research Project
Grant-in-Aid for Young Scientists (B)
Inactivation of RB gene is frequently found during tumor progression and correlated with drug resistance or undifferentiated state in some kinds of cancer. We previously found that RB inactivation contributes to the acquisition of stem cell-like activity via activation of inflammatory signaling. But the receptors of some cytokines induced by RB inactivation such as CCL2 were not expressed in tumor cells themselves. Up-regulation of CCL2 secretion was dependent on ROS accumulation and subsequent JNK activation caused by RB inactivation. RB inactivated myofibrosarcoma cells highly expressed CCL2. And these cells showed higher tumorigenic activity in wild type mice but not in CCR2 knockout mice. Angiogenesis and infiltration of Gr-1 positive cells into tumor microenvironment were decreased in CCR2 knockout mice compared with wild type mice. Here we state that CCL2 induced by RB inactivation contributes to the formation of tumor-promoting inflammatory microenvironment.
All 2015 2014 2013
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 1 results)
STEM CELLS
Volume: - Issue: 5 Pages: 1657-1669
10.1002/stem.1971
Molecular and Cellular Biology
Volume: 33 Issue: 16 Pages: 3113-3124
10.1128/mcb.01597-12
120005312327
