Research Project
Grant-in-Aid for Young Scientists (B)
We found that a SUMO E3 ligase RFP and de-ubiquitiantion enzyme USP7 stabilise p53 protein through their interaction. USP7 contribute to the stabilisation of RFP and stabilised RFP SUMOylate p53 at lysine 386 residue. We further showed that both USP7 and RFP confer cancer cells resistance to UV-induced apoptosis in a p53 expression dependent manner. These data suggest that USP7 and RFP increase the cell survival during DNA damage by stabilising p53 protein.
All 2015 2014 2013
All Journal Article (7 results) (of which Peer Reviewed: 7 results, Open Access: 4 results, Acknowledgement Compliant: 1 results) Presentation (4 results)
Cancer Research
Volume: 75 Issue: 5 Pages: 813-823
10.1158/0008-5472.can-14-1317
Endocrine Journal
Volume: 62 Issue: 2 Pages: 153-160
10.1507/endocrj.EJ14-0369
130004700287
EMBO Journal.
Volume: 33 Issue: 18 Pages: 2098-2112
10.15252/embj.201488289
Cell reports.
Volume: 7 Issue: 4 Pages: 1156-1167
10.1016/j.celrep.2014.03.068
Cancer Sci.
Volume: 105 Issue: 5 Pages: 545-52
10.1111/cas.12390
PLoS One
Volume: 9 Issue: 1 Pages: e83385-e83385
10.1371/journal.pone.0083385
J. Biol. Chem.
Volume: 288 Issue: 15 Pages: 10459-10471
10.1074/jbc.m112.421966