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Blood platelet-to-cancer cell fusion and metastasis

Research Project

Project/Area Number 25830079
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionKyoto University

Principal Investigator

MORIOKA YOKO  京都大学, 人間・環境学研究科(研究院), 研究員 (50598349)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血小板 / がん / 細胞融合
Outline of Final Research Achievements

While the contribution of blood platelets to carcinogenesis has been known for more than a century, the molecular mechanisms through which they do so remain poorly understood. Our work has established that blood platelets have the abilities to fuse with specific cancer cell lines. By fusing with platelets, cancer cells were found to undergo transcriptional reprogramming and display enhanced adhesive abilities. These findings may provide novel therapeutic opportunities for the treatment of metastatic cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Critical roles for murine Reck in the regulation of vascular patterning and stabilization2015

    • Author(s)
      Glicia Maria de Almeida, Mako Yamamoto, Yoko Morioka, Shuichiro Ogawa, Tomoko Matsuzaki and Makoto Noda
    • Journal Title

      Scientific Reports

      Volume: 5 Pages: 17860-17869

    • NAID

      120005818244

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.2014

    • Author(s)
      Morioka Y et al.
    • Journal Title

      Blood

      Volume: 123(21) Issue: 21 Pages: 3344-4453

    • DOI

      10.1182/blood-2013-10-531392

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A novel cleavage-resistant and highly prothrombotic von Willebrand factor mutant2013

    • Author(s)
      Nicolas Prevost, Yoko Morioka, Caterina Casari, Sachiko Kurata, Olivier Christophe, Cecile Denis
    • Organizer
      The International Society on Thrombosis and Haemostasis 2013
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of exogenous proteins in platelets: All you need is Yop2013

    • Author(s)
      Nicolas Prevost, Stefan Woelke, Sachiko Kurata, Yoko Morioka, Juergen Heesemann, Guy Cornelis
    • Organizer
      The International Society on Thrombosis and Haemostasis 2013
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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