Role of NDRG1 in tumor angiogenesis through activation of tumor-associated macrophages and vascular endothelial cells.
| Project/Area Number |
25830083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyushu University |
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Principal Investigator |
WATARI Kosuke 九州大学, 薬学研究科(研究院), 助教 (90596834)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | NDRG1 / 血管新生 / マクロファージ / 血管内皮細胞 / VEGF / がん / M-CSF |
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| Outline of Final Research Achievements |
N-myc downstream regulated gene 1 (NDRG1) has been known to play pleiotropic roles in cell growth, development and differentiation. We have previously reported that NDRG1 expression levels in cancer cells are correlated with tumor growth and angiogenesis in both experimental model and human tumor. However, whether tumor growth and angiogenesis could be affected by NDRG1 in host remains unclear. This study demonstrated that NDRG1 deficiency suppressed infiltration and activation of tumor-associated macrophages in tumor. Moreover, NDRG1 deficiency specifically suppressed VEGF-induced angiogenesis in vascular endothelial cells. Thus, NDRG1 plays a critical role in tumor growth and tumor angiogenesis through tumor-associated macrophages and vascular endothelial cells.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Tumor-derived Interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages2014
Author(s)
Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi, H, Takahashi T, Kage M, Kuwano M, Ono M.
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Journal Title
PLoS ONE
Volume: 9
Issue: 6
Pages: e99568-e99568
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.2014
Author(s)
Watari, K., Shibata, T., Kawahara, A., Sata, K., Nabeshima, H., Shinoda, A., Abe, H., Azuma, K., Murakami, Y., Izumi, H., Takahashi, T., Kage, M., Kuwano, M., Ono, M.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Tumor-derived interleukin-1 promotes lymphangiogenesis, and lymph node metastasis through activation of M2-type macrophages by lung cancer cells.2014
Author(s)
Kosuke Watari, Tomohiro Shibata, Akihiko Kawahara, Yuichi Murakami, Hiroshi Nabeshima, Ai Shinoda, Koichi Azuma, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono.
Organizer
AACR Annual Meeting 2014
Place of Presentation
San Diego, CA
Year and Date
2014-04-05 – 2014-04-09
Related Report
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