Elucidation of the mechanism of maintenance of quiescence in cancer stem cells
| Project/Area Number |
25830084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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|---|
| Keywords | がん幹細胞 / 細胞周期 / 静止期 / タンパク質分解 / ユビキチン / Fbxw7 / 乳がん |
|---|
| Outline of Final Research Achievements |
In addition to the properties of self-renewal and multipotency, cancer stem cells share the characteristics of their distinct cell cycle status with somatic stem cells. Cancer stem cells (CSCs) are maintained in a quiescent state (G0 phase) with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of the mechanisms of CSC quiescence might therefore be expected to provide further insight into CSC behaviors and lead to the elimination of cancer. In this project, with the aim of deciphering the mechanism of maintenance of quiescence in breast cancer stem cells, we generated mouse models of this cancer and several breast cancer cell lines deficient in putative G0 maintenance factor.
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Report
(3 results)
Research Products
(29 results)
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[Book] 臨床血液2014
Author(s)
武石 昭一郎
Total Pages
1
Publisher
日本血液学会
Related Report
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[Book] 実験医学2013
Author(s)
武石 昭一郎、中山 敬一
Total Pages
4
Publisher
羊土社
Related Report
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