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Analysis of circulating tumor cells using an ultra-low-invasive cell separation device

Research Project

Project/Area Number 25830099
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionNagoya University

Principal Investigator

Yusa Akiko  名古屋大学, 工学(系)研究科(研究院), 招へい教員 (00455536)

Co-Investigator(Renkei-kenkyūsha) NAKANISHI Hayao  愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (20207830)
KYOGASHIMA Mamoru  日本薬科大学, 薬学部, 教授 (50225091)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords個別化医療 / 血液循環癌細胞 / 癌の個性診断 / 一細胞解析
Outline of Final Research Achievements

Characterization of Circulating Tumor Cells (CTCs), it is necessary to practical use in personalized medicine of cancer. In recent research, the technology of detection, isolation and separation of CTC from whole blood is progressed steadily. In order to optimize methods of genetic analysis that follows a step of CTC collection, we tested many kinds of method of nucleic acid amplification and genetic analysis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Liquid Biopsy の基礎的概念と臨床への展開2016

    • Author(s)
      遊佐亜希子
    • Journal Title

      月刊「細胞」

      Volume: 48 Pages: 229-232

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter2015

    • Author(s)
      Yamamoto S, Fei J, Okochi M, Shimizu K, Yusa A, Kondo N, Iwata H, Nakanishi H, Honda H
    • Journal Title

      Bioprocess and biosystems engineering

      Volume: 38 Issue: 9 Pages: 1693-1704

    • DOI

      10.1007/s00449-015-1412-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a New Rapid Isolation Device for Circulating Tumor Cells (CTCs) Using 3D Palladium Filter and Its Application for Genetic Analysis2014

    • Author(s)
      30) A Yusa, M Toneri, T Masuda, M Okochi, H Iwata, H Honda, F Arai, H Nakanishi.
    • Journal Title

      PLOS ONE

      Volume: 9(2):e88821 Issue: 2 Pages: 1-11

    • DOI

      10.1371/journal.pone.0088821

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 磁気捕捉カラムとサイズ選択性フィルターを用いた血中循環癌細胞の捕捉法の開発2015

    • Author(s)
      山本修平,清水一憲,遊佐亜希子,近藤直人,岩田広治,中西速夫,本多裕之
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規ディスポ型CTC分離デバイスを用いた肺がん,乳がん等のLiquid biopsyに関する 前臨床的および臨床的検討2015

    • Author(s)
      遊佐亜希子,岩田広治,吉田達哉,谷田部恭,本多裕之,新井史人,中西速夫
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規CTC分離デバイスを用いた担がんマウスモデルにおけるCTCの動態解析2014

    • Author(s)
      中西速夫、寺澤佳世子、益田泰輔、山本修平、岩田広治、近藤直人、伊藤誠二、新井史人、本多裕之、遊佐亜希子
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] ヘパラン硫酸JM403抗原の細胞質内顆粒状発現は、上皮細胞の増殖・分化に関与する2013

    • Author(s)
      遊佐亜希子、藤井正宏、小田高司、伊東良子、伊東丈夫、高橋響、京ケ島守
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪・大阪国際交流センター
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of a new rapid isolation device for circulating tumor cells (CTCs) and its application2013

    • Author(s)
      Akiko Yusa, Makoto Toneri, Taisuke Masuda, Shuhei Yamamoto, Mina Okochi, Seiji Ito, Hiroji Iwata, Eisaku Kondo, Yoshinobu Baba, Hiroyuki Honda, Fumihito Arai, Hayao Nakanishi
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Isolation of Living Circulating Tumor Cells (CTCs) from Peripheral Blood Using Size-Based Devices and their Application to CTC Biology in Mice2013

    • Author(s)
      Akiko Yusa, Yumi Matsumoto, Kayoko Terazawa, Taisuke Masuda, Fumihito Arai and Hayao Nakanishi
    • Organizer
      24th 2013 International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      名古屋・名古屋大学
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 末梢血循環腫瘍細胞又は希少細胞分離用デバイス2014

    • Inventor(s)
      遊佐亜希子、中西速夫ほか6名
    • Industrial Property Rights Holder
      遊佐亜希子、中西速夫ほか6名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-23
    • Related Report
      2014 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 末梢循環腫瘍細胞又は希少細胞分離用デバイス2013

    • Inventor(s)
      遊佐亜希子、中西速夫ほか5名
    • Industrial Property Rights Holder
      遊佐亜希子、中西速夫ほか5名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-153717
    • Filing Date
      2013-07-24
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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