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The clinical utility for IHC ki67 after pre-operative short term hormone therapy

Research Project

Project/Area Number 25830101
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionOkayama University

Principal Investigator

IWAMOTO Takayuki  岡山大学, 医学部, 客員研究員 (40627238)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords乳癌 / バイオマーカー / 遺伝子マーカー / 免疫染色Ki67 / 術前短期ホルモン療法 / 術前療法 / ホルモン療法 / IHC Ki67 / サンプル収集 / 学会参加 / 術前短期ホルモン / 遺伝子プロファイリング
Outline of Final Research Achievements

Recently, IHC Ki67 after short-term hormone therapy is one of the hot topics to omit unnecessary chemotherapy for hormone receptor positive breast cancers. However, its biological processes have not been unknown.
In this study we are under investigating IHC Ki67 and genomic profiling before and after short-term hormone therapy. So far, we have completed the collection of samples and immunological study. However, it will take another time to perform profiling of samples, because of maintenance of equipment, failure, etc. After the new research collaborations with Tokushima University will be allowed by the clinical trials committee at our institution, we will resume the profiling of samples. The results will be coming.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2013

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (3 results)

  • [Journal Article] Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers2013

    • Author(s)
      Mitsuya Itoh; Takayuki Iwamoto; Junji Matsuoka; Tomohiro Nogami; Takayuki Motoki; Tadahiko Shien; Naruto Taira; Naoki Niikura; Naoki Hayashi; Shoichiro Ohtani; Kenji Higaki; Toshiyoshi Fujiwara; Hiroyoshi Doihara; W. Fraser Symmans; Lajos Pusztai
    • Journal Title

      Breast Cancer Res Treat

      Volume: 143(2) Issue: 2 Pages: 403-9

    • DOI

      10.1007/s10549-013-2763-z

    • NAID

      120005469525

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase2013

    • Author(s)
      Xiaoping Wang, Hitomi Saso, Takayuki Iwamoto, Weiya Xia, Yun Gong, Lajos Pusztai, Wendy A. Woodward, James M. Reuben, Steven L. Warner, David J. Bearss, Gabriel N. Hortobagyi, Mien-Chie Hung, Naoto T. Ueno
    • Journal Title

      Cancer Res

      Volume: 73(21)

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uncovering the molecular secrets of Inflammatory Breast Cancer biology: An integrated analysis of three distinct Affymetrix gene expression data sets2013

    • Author(s)
      Steven J. Van Laere, Naoto T. Ueno, Pascal Finetti, Peter Vermeulen, Anthony Lucci, Fredika M. Robertson, Melike Marsan, Takayuki Iwamoto, Savitri Krishnamurthy, Hiroko Masuda, Peter van Dam, Wendy A. Woodward, Patrice Viens, Massimo Cristofanilli, Daniel Birnbaum, Luc Dirix, James M. Reuben, and François Bertucci
    • Journal Title

      Clinical cancer reserach

      Volume: 1;19(17) Pages: 4685-96

    • Related Report
      2013 Research-status Report
  • [Journal Article] Bayesian Mixture Models for Assessment of Gene Differential Behaviour and Prediction of pCR through the Integration of Copy Number and Gene Expression Data2013

    • Author(s)
      Trentini, F. Ji, Y. Iwamoto, T. Qi, Y. Pusztai, L. Muller, P.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e68071-e68071

    • DOI

      10.1371/journal.pone.0068071

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories2013

    • Author(s)
      Szekely, B. Iwamoto, T. Szasz, A. M. Qi, Y. Matsuoka, J. Symmans, W. F. Tokes, A. M. Kulka, J. Swanton, C. Pusztai, L.
    • Journal Title

      Breast Cancer Res Treat

      Volume: 138 Issue: 3 Pages: 691-8

    • DOI

      10.1007/s10549-013-2475-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes2013

    • Author(s)
      Santarpia, L. Iwamoto, T. Di Leo, A. Hayashi, N. Bottai, G. Stampfer, M. Andre, F. Turner, N. C. Symmans, W. F. Hortobagyi, G. N. Pusztai, L. Bianchini, G.
    • Journal Title

      Oncologist

      Volume: 18 Issue: 10 Pages: 1063-73

    • DOI

      10.1634/theoncologist.2013-0163

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Women prefer adjuvant endocrine therapy to chemotherapy for breast cancer treatment2013

    • Author(s)
      Niikura, N. Kimura, M. Iwamoto, T. Hayashi, N. Shintoku, J. Saito, Y. Suzuki, Y. Tokuda, Y.
    • Journal Title

      Breast Cancer

      Volume: 20 Issue: 1 Pages: 67-74

    • DOI

      10.1007/s12282-011-0310-5

    • NAID

      10031164583

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes2013

    • Author(s)
      Masuda, H. Brewer, T. M. Liu, D. D. Iwamoto, T. Shen, Y. Hsu, L. Willey, J. S. Gonzalez-Angulo, A. M. Chavez-Macgregor, M. Fouad, T. M. Woodward, W. A. Reuben, J. M. Valero, V. Alvarez, R. H. Hortobagyi, G. N. Ueno, N. T.
    • Journal Title

      Ann Oncol

      Volume: 25(2) Issue: 2 Pages: 384-91

    • DOI

      10.1093/annonc/mdt525

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers2013

    • Author(s)
      Masuda, H. Baggerly, K. A. Wang, Y. Iwamoto, T. Brewer, T. Pusztai, L. Kai, K. Kogawa, T. Finetti, P. Birnbaum, D. Dirix, L. Woodward, W. A. Reuben, J. M. Krishnamurthy, S. Symmans, W. F. Van Laere, S. J. Bertucci, F. Hortobagyi, G. N. Ueno, N. T.
    • Journal Title

      Breast Cancer Res

      Volume: 15 Issue: 6

    • DOI

      10.1186/bcr3579

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells2013

    • Author(s)
      Kai, K. Iwamoto, T. Kobayashi, T. Arima, Y. Takamoto, Y. Ohnishi, N. Bartholomeusz, C. Horii, R. Akiyama, F. Hortobagyi, G. N. Pusztai, L. Saya, H. Ueno, N. T.
    • Journal Title

      Oncogene

      Volume: 23;33(4) Pages: 440-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas2013

    • Author(s)
      Delpech, Y. Coutant, C. Hsu, L. Barranger, E. Iwamoto, T. Barcenas, C. H. Hortobagyi, G. N. Rouzier, R. Esteva, F. J. Pusztai, L.
    • Journal Title

      Br J Cancer

      Volume: 108 Issue: 2 Pages: 285-91

    • DOI

      10.1038/bjc.2012.557

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Statin use in primary inflammatory breast cancer: a cohort study2013

    • Author(s)
      Brewer, T. M. Masuda, H. Liu, D. D. Shen, Y. Liu, P. Iwamoto, T. Kai, K. Barnett, C. M. Woodward, W. A. Reuben, J. M. Yang, P. Hortobagyi, G. N. Ueno, N. T.
    • Journal Title

      Br J Cancer

      Volume: 109 Pages: 318-24

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers2013

    • Author(s)
      Bianchini, G. Pusztai, L. Karn, T. Iwamoto, T. Rody, A. Kelly, C. M. Muller, V. Schmidt, M. Qi, Y. Holtrich, U. Becker, S. Santarpia, L. Fasolo, A. Del Conte, G. Zambetti, M. Sotiriou, C. Haibe-Kains, B. Symmans, W. F. Gianni, L.
    • Journal Title

      Breast Cancer Res

      Volume: 15 Issue: 5

    • DOI

      10.1186/bcr3481

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival2013

    • Author(s)
      Bertucci, F. Ueno, N. T. Finetti, P. Vermeulen, P. Lucci, A. Robertson, F. M. Marsan, M. Iwamoto, T. Krishnamurthy, S. Masuda, H. Van Dam, P. Woodward, W. A. Cristofanilli, M. Reuben, J. M. Dirix, L. Viens, P. Symmans, W. F. Birnbaum, D. Van Laere, S. J.
    • Journal Title

      Ann Oncol

      Volume: 25 Issue: 2 Pages: 358-65

    • DOI

      10.1093/annonc/mdt496

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] HER2陽性乳がんにおける免疫関連遺伝子のバイオマーカーとしての可能性: 2,091例の検討2013

    • Author(s)
      岩本高行、松岡順治、新倉直樹、林直輝、河田健吾、 鳩野みなみ 、伊藤麻衣子、西山慶子、溝尾妙子、野上智弘、 元木崇之、枝園忠彦、平成人、藤原俊義、土井原博義、Giampaolo Bianchini
    • Organizer
      日本乳癌学会学術総会
    • Place of Presentation
      浜松
    • Related Report
      2013 Research-status Report
  • [Presentation] ER陰性/PR陽性乳がんにおけるER mRNAの発現とMolecularサブタイプ2013

    • Author(s)
      岩本高行、松岡順治、鳩野みなみ、伊藤麻衣子、溝尾妙子、野上智弘、元木崇之、枝園忠彦、平成人、林直輝、新倉直樹、藤原俊義、土井原博義
    • Organizer
      第51回 日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Estrogen receptor (ER) mRNA expression and molecular subtype distribution in breast cancers that are ER-negative but progesterone receptor-positive by immunohistochemistory2013

    • Author(s)
      Takayuki Iwamoto, Junji Matsuoka, Tomohiro Nogami, Takayuki Motoki, Tadahiko Shien, Naruto Taira, Naoki Niikura, Naoki Hayashi, Toshiyoshi Fujiwara, Hiroyoshi Doihara, W Fraser Symmans, Lajos Pusztai
    • Organizer
      San Antonio breast cancer symposium
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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