Diffuse optical spectroscopic imaging of early prediction of cancer response to chemotherapy
Project/Area Number |
25830105
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnostics
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Research Institution | Saitama Medical University |
Principal Investigator |
UEDA SHIGETO 埼玉医科大学, 医学部, 講師 (20646947)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 拡散光スペクトロスコピー / 乳癌 / 薬物療法 / 血管新生阻害薬 / 治療効果判定 / バイオマーカー / 乳がん / 近赤外光イメージング / ヘモグロビン / 酸素飽和度 / 血管新生 / 低酸素 |
Outline of Final Research Achievements |
Diffuse optical spectroscopic imaging (DOSI) techniques for measuring tissue total hemoglobin (tHb) concentration and oxygen saturation (SO2) have been recently accepted as a way to assess tumor vascularity and oxygenation. First, we evaluated the usefulness of time-resolved DOSI (TRS, Hamamatsu K.K, Hamamatus, Japan) for functional imaging of primary breast cancer. Tumors showed unique features of higher rtHb (the relative value of tumor tHb normalized by normal breast tHb) with a wider range of SO2 than normal breast tissue. There was a significant correlation of rtHb with tumor aggressiveness. Second, we conducted a clinical study with neoadjuvant chemotherapy monitored by DOSI and revealed DOSI could predict a pathological complete response (pCR) at the early time points. We believe DOSI for determination of tumor tHb and SO2 could be useful for prediction of patient prognosis and potential response to treatment.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Near-infrared diffuse optical imaging for early prediction of breast cancer response to neoadjuvant chemotherapy: a comparative study using FDG-PET/CT.2016
Author(s)
Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Ogura H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
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Journal Title
J Nucl Med
Volume: Ahead of print
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Optical imaging for monitoring tumor oxygenation response after initiation of single-agent bevacizumab followed by cytotoxic chemotherapy in breast cancer patients.2014
Author(s)
Ueda S, Kuji I, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T.
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Journal Title
PLoS One
Volume: 6;9(6)
Issue: 6
Pages: e98715-e98715
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.2014
Author(s)
Nakamiya N, Ueda S, Shigekawa T, Takeuchi H, Sano H, Hirokawa E, Shimada H, Suzuki H, Oda M, Osaki A, Saeki T.
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Journal Title
Cancer Sci
Volume: 105(7):
Issue: 7
Pages: 833-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Near-infrared diffuse optical imaging for early prediction of breast cancer response to neoadjuvant chemotherapy: a comparative study using FDG-PET/CT.2015
Author(s)
Ogura H, Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
Organizer
サンアントニオ乳癌シンポジウム(サンアントニオ、アメリカ)
Place of Presentation
Gonzalez Convention Center
Year and Date
2015-12-08
Related Report
Int'l Joint Research
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