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Glyco-alteration-based clinical re-evaluation of existing serum biomarkers for ovarian carcinoma

Research Project

Project/Area Number 25830106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionKyoto Sangyo University

Principal Investigator

AKITA Kaoru  京都産業大学, 総合生命科学部, 助教 (10449506)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords卵巣癌 / 子宮内膜症 / 腫瘍マーカー / 糖鎖
Outline of Final Research Achievements

The epithelial ovarian carcinoma (EOC) is an aggressive malignant tumor, and is currently the leading cause of gynecologic cancer death. CA125 is the most commonly used serum marker for EOC, but shows a high-false positive rate for several benign diseases such as endometriosis. The purpose of this study is therefore to identify a useful biochemical tool for detecting qualitative differences between CA125 from patients with endometriosis and EOC, and to facilitate differential diagnosis of these diseases. In this study, we found that the mesothelin-binding ability of serum CA125 was significantly higher in patients with EOC than in patients with endometriosis. Our results suggest that the mesothelin-binding ability may be a useful indicator for qualitatively evaluating CA125 in patients with endometriosis and EOC.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Difference in mesothelin-binding ability of serum CA125 between patients with endometriosis and epithelial ovarian cancer2015

    • Author(s)
      Sasaki A, Akita K, Ito F, Mori T, Kitawaki J, Nakada H
    • Journal Title

      Int J Cancer

      Volume: 136 Issue: 8 Pages: 1985-1990

    • DOI

      10.1002/ijc.29185

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮内膜症患者と卵巣癌患者間における血清CA125のメソテリン結合能の違い2014

    • Author(s)
      秋田 薫、佐々木 綾、菅沼 泉、森 泰輔、北脇 城、中田 博
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都産業大学総合生命科学部 中田研ホームページ

    • URL

      http://www.cc.kyoto-su.ac.jp/~kakita/nakadaken/Home.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 卵巣癌の検出方法、卵巣癌と子宮内膜症との鑑別方法、並びに、キット2014

    • Inventor(s)
      中田博、秋田薫、北脇城、佐々木綾
    • Industrial Property Rights Holder
      学校法人京都産業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-159753
    • Filing Date
      2014-08-05
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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