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The development of a novel type of cancer preventive medicine that targets cell competition

Research Project

Project/Area Number 25830109
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionUniversity of Yamanashi (2014-2015)
Hokkaido University (2013)

Principal Investigator

YAMAUCHI Hajime  山梨大学, 総合研究部, 助教 (50541273)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords癌 / 細胞・組織 / 細胞競合 / ケミカルバイオロジー / 抗がん物質探索 / 組織
Outline of Final Research Achievements

Our recent studies have revealed that cell competition can occur between normal and transformed epithelial cells, and normal epithelial cells recognize the presence of the neighboring transformed cells and actively eliminate them cells from epithelial tissues. We forcused this interaction and established the screening platform that targets cell competition. By using this platform, we have identified VC1 as a hit compound that specifically promotes elimination of RasV12-transformed cells from the epithelium. Among several VC1 derivative compounds, we have found that VC1-8 has least cytotoxicity against normal cells but shows the comparable effect on the elimination of transformed cells. This cell competition activity of VC1-8 is observed both in vitro and ex vivo, indicating that VC1-8 is a promising novel type of cancer preventive medicine.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia.2015

    • Author(s)
      Yamauchi, H., Matsumaru, T., Morita, T., Ishikawa, S., Maenaka, K., Takigawa, I., Semba, K., Kon, S. and Fujita, Y.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 15336-15336

    • DOI

      10.1038/srep15336

    • NAID

      120005674073

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 細胞競合を促進する低分子化合物のハイスループットスクリーニング2014

    • Author(s)
      山内肇
    • Organizer
      第一回六甲医学研究会
    • Place of Presentation
      六甲山ホテル(兵庫県神戸市)
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] High-throughput screening of small compounds that enhance the ability of cell competition2014

    • Author(s)
      山内肇
    • Organizer
      第十二回未来創薬・医療イノベーション拠点形成国際シンポジウム
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] がん細胞に対する正常細胞の細胞競合力を高める化合物のハイスループットスクリーニングと機能解析2014

    • Author(s)
      山内肇
    • Organizer
      第二回がん細胞競合イメージング研究会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2014-07-29 – 2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 正常細胞によるがん細胞の排除を促進する低分子化合物の探索と解析

    • Author(s)
      山内肇
    • Organizer
      第三回 細胞競合コロキウム
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2013 Research-status Report
  • [Remarks] がん予防薬の発見につながるスクリーニング系の開発に世界で初めて成功

    • URL

      http://www.hokudai.ac.jp/news/151026_cris_pr.pdf

    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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