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The mechanisms of macrophage dependent vaccine

Research Project

Project/Area Number 25830115
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionMie University

Principal Investigator

MURAOKA Daisuke  三重大学, 医学(系)研究科(研究院), 助教 (20608955)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsがんワクチン
Outline of Final Research Achievements

Previously we had identified that macrophage has critical role in the induction of immune responses elicited with CHP cancer vaccine (Macrophage oriented vaccine). In this study, to reveal the mechanisms of immune response induced with macrophage oriented vaccine, we compared with CHP cancer long peptide vaccine and the long peptide vaccine emulsified with IFA (classical dendritic cell dependent vaccine). As a result, we had demonstrated that the medullary macrophage has a critical role in macrophage oriented vaccine. Furthermore, we had shown the detailed mechanism which is involved in the efficacy of this vaccine system.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation.2014

    • Author(s)
      Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 9 Pages: e108494-e108494

    • DOI

      10.1371/journal.pone.0108494

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Nanogel-based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Anti-Tumor Immunity2014

    • Author(s)
      D. Muraoka, N. Harada, T. Hayashi, Y. Tahara, F. Momose, S. Sawada, S. Mukai, K. Akiyoshi, H. Shiku,
    • Journal Title

      ACS nano

      Volume: 8 Issue: 9 Pages: 9209-9218

    • DOI

      10.1021/nn502975r

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Systemic CD8+ T Cell-Mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-Induced Tumor Necrosis Factor Receptor.2014

    • Author(s)
      Ishihara M, Seo N, Mitsui J, Muraoka D, Tanaka M, Mineno J, Ikeda H, Shiku H.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e104669-e104669

    • DOI

      10.1371/journal.pone.0104669

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] CHPナノゲルはロングペプチド抗原をリンパ節内のマクロファージに抗原提示させる2013

    • Author(s)
      村岡 大輔、原田 直純、林 妙、百瀬 文康、澤田 晋一、秋吉 一成、珠玖 洋
    • Organizer
      第17回 日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部
    • Related Report
      2013 Research-status Report
  • [Presentation] Peptide Sequence Design and Delivery System Are Critical for the Immunogenicity of Long Peptide-Based Cancer Vaccines2013

    • Author(s)
      Daisuke Muraoka, Naozumi Harada, Tae Hayashi, Kazunari Akiyoshi, and Hiroshi Shiku
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Macrophage is a good target as antigen presenting cell to induce strong immune responses elicted with administration of vaccination antigen and immunological adjuvant2013

    • Author(s)
      MURAOKA Daisuke, HARADA Naozumi, HAYASHI Tae, MOMOSE Fumiyasu, SAWADA Shin-ichi, AKIYOSHI Kazunari, SHIKU Hiroshi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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