| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Cancer relapse is often seen even after curative operation followed by adjuvant chemotherapy. In this study, we analyzed cancer cell colonies that emerge in the presence of anticancer drugs (drug-tolerant colonies, DTCs) as a cancer relapse model. Proteomic characterization of DTCs identified two major subgroups, but none of these characters associated with DTCs. A lead compound screening identified an RNA polymerase inhibitor (RNAPi) bearing potency in DTC suppression. RNAPi with cisplatin significantly reduced the number of nodules of peritoneal dissemination of gastric cancer in mice. These findings suggest that RNAPi is potent in suppression of cancer relapse such as peritoneal dissemination of gastric cancer.
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