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Molecular analysis of platelet-dependent tumor cell proliferation

Research Project

Project/Area Number 25830125
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

TAKAGI Satoshi  公益財団法人がん研究会, がん化学療法センター, 研究員 (20582240)

Research Collaborator SATO Shigeo  
OH-HARA Tomoko  
TAKAMI Miho  
NODA Sachie  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords骨肉腫 / 血小板 / 血小板凝集 / PDGF / Akt / 癌 / 分子標的治療
Outline of Final Research Achievements

In this study, we clarified the signal transduction pathway which was activated in cancer cells by the interaction with platelets and investigated the efficacy of inhibitors which target the identified pathway. We found that osteosarcoma cells could activate platelets via the direct cell-cell interaction and the PDGF-BB released by activated-platelets activated PDGFR-Akt axis in the osteosarcoma cells. Furthermore, we found that Sunitinib, a PDGFR inhibitor, and LY294002, a PI3K inhibitor, suppressed platelet-dependent sarcoma cells proliferation. These findings suggest that these inhibitors targeting PI3K-Akt axis and/or anti-platelet agents might be the anti-tumor drugs.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Suppression of Aggrus/podoplanin-induced platelet aggregation and pulmonary metastasis by a single-chain antibody variable region fragment.2014

    • Author(s)
      Kenichi Miyata, Satoshi Takagi, Shigeo Sato, Hiroshi Morioka, Kiyotaka Shiba, Tamiko Minamisawa, Miho Takami, and Naoya Fujita
    • Journal Title

      Cancer Med.

      Volume: 3 Issue: 6 Pages: 1595-1604

    • DOI

      10.1002/cam4.320

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Platelets promote osteosarcoma cell growth through activation of the PDGFR-Akt signaling axis.2014

    • Author(s)
      Satoshi Takagi, Ai Takemoto, Miho Takami, Tomoko Oh-hara, and Naoya Fujita
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 8 Pages: 983-988

    • DOI

      10.1111/cas.12464

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis2014

    • Author(s)
      Takagi S, Oh-hara T, Sato S, Gong B, Takami M, Fujita N.
    • Journal Title

      International Journal of Cancer

      Volume: 134 Issue: 11 Pages: 2605-2614

    • DOI

      10.1002/ijc.28602

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.2013

    • Author(s)
      Takagi S, Sato S, Oh-hara T, Takami M, Koike S, Mishima Y, Hatake K, Fujita N.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e73609-e73609

    • DOI

      10.1371/journal.pone.0073609

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Platelets promote the malignancy of osteosarcoma through activation of the PDGFR-Akt signaling2014

    • Author(s)
      竹本愛、高木聡、高見美穂、大原智子、藤田直也
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis2014

    • Author(s)
      大原智子、高木聡、竹本愛、佐藤重男、高見美穂、藤田直也
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 一本鎖抗体によるAggrus/podoplanin依存的な血小板凝集及び肺転移の抑制。2014

    • Author(s)
      宮田憲一、高木聡、藤田 直也
    • Organizer
      第23回日本がん転移学会
    • Place of Presentation
      金沢市文化ホール、金沢
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.2014

    • Author(s)
      Satoshi Takagi, Shigeo Sato, Tomoko Oh-hara, Miho Takami, Sumie Koike, and Naoya Fujita
    • Organizer
      AACR-Special Conference 2014 Cellular Heterogeneity in the Tumor Microenvironment
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of anti-Aggrus/podoplanin antibodies suppressing hematogenous metastasis and tumor growth in vivo2013

    • Author(s)
      藤田直也、高木聡
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Suppression of tumor growth in vivo by a murine/human chimeric anti-Aggrus neutralizing antibody2013

    • Author(s)
      高木聡、佐藤重男、藤田直也
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Aggrus/podoplaninを標的とした中和抗体による抗転移効果と抗腫瘍効果2013

    • Author(s)
      高木聡、藤田直也
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      ホテルブエナビスタ、松本
    • Related Report
      2013 Research-status Report
  • [Remarks] 公益財団法人がん研究会がん化学療法センター基礎研究部ホームページ

    • URL

      http://www.jfcr.or.jp/chemotherapy/department/fundamental/index.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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