Intracellular self-organization of actin cytoskeleton
| Project/Area Number |
25830147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUJITA Masashi 独立行政法人理化学研究所, 生命システム研究センター, 研究員 (80564749)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 細胞骨格 / アクチン / ミオシン / 細胞動態 / RhoGAP / アクチン細胞骨格 / 細胞内局在 / Rho / 線虫 |
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| Outline of Final Research Achievements |
Actin filaments and myosin motor form network at the cell cortex and generate contractile forces. This actomyosin network form pulsatile foci in the cell cortex of the one-cell embryos of the nematode C. elegans. In this study, I investigated how the foci structure is regulated. I found that RhoGAP proteins RGA-3/4 colocalize to the actomyosin foci. Experiments showed that RGA-3/4 regulate the size and disassembly of actomyosin foci.
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Report
(3 results)
Research Products
(5 results)
