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Intracellular self-organization of actin cytoskeleton

Research Project

Project/Area Number 25830147
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field System genome science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

FUJITA Masashi  独立行政法人理化学研究所, 生命システム研究センター, 研究員 (80564749)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords細胞骨格 / アクチン / ミオシン / 細胞動態 / RhoGAP / アクチン細胞骨格 / 細胞内局在 / Rho / 線虫
Outline of Final Research Achievements

Actin filaments and myosin motor form network at the cell cortex and generate contractile forces. This actomyosin network form pulsatile foci in the cell cortex of the one-cell embryos of the nematode C. elegans. In this study, I investigated how the foci structure is regulated. I found that RhoGAP proteins RGA-3/4 colocalize to the actomyosin foci. Experiments showed that RGA-3/4 regulate the size and disassembly of actomyosin foci.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 2013

All Presentation (5 results)

  • [Presentation] Colocalization of RhoGAP Restricts the Size of Pulsatile Actomyosin Foci in C. elegans Embryos2014

    • Author(s)
      Fujita M., Onami S.
    • Organizer
      The 2014 ASCB/IFCB Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Colocalization of RhoGAP Restricts the Size of Pulsatile Actomyosin Foci in C. elegans Embryos2014

    • Author(s)
      Fujita M., Onami S.
    • Organizer
      The 62nd NIBB Confrnce "Force in Development"
    • Place of Presentation
      岡崎コンファレンスセンター(岡崎市)
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Morphology of actomyosin network is regulated by colocalization of RhoGAP RGA-3/42014

    • Author(s)
      Fujita M., Onami S.
    • Organizer
      C. elegans Development, Cell Biology and Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Year and Date
      2014-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] RhoGAP proteins RGA-3/4 mediate spatial negative feedback of the actomyosin in C. elegans embryos2013

    • Author(s)
      藤田征志, 大浪修一
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of colocalization between RhoGAP protein RGA-3/4 and actomyosin in C. elegans embryos2013

    • Author(s)
      藤田征志, 大浪修一
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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