| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
One of the fundamental questions in understanding tissue development is how multipotent progenitors/tissue stem cells give rise to various cell types in a defined order to achieve appropriate tissue organization. Neural stem/progenitor cells (NPCs) attract much attention since these cells give rise to a sequence of neuronal and glial cell types in a developmental-stage dependent manner with striking precision. Previously, we have shown that high mobility group A (HMGA) proteins play pivotal roles in driving fate switches of NPCs during neocortical development. In this study, we identified the genes Imp2, which is upregulated by HMGA proteins, as novel regulators of neurogenic potential of NPCs.
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