Regulation of chromatin structure and gene expression in cross-tolerance to environmental stress
Project/Area Number |
25840007
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Molecular biology
|
Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | ストレス応答 / シグナル伝達 / 遺伝子発現制御 / クロマチン / 分子生物学 |
Outline of Final Research Achievements |
We have studied cellular responses to low-dose environmental stress. Cross-tolerance is an adaptive phenomenon, in which exposure to low-dose stress confers transient resistance to other form of high-dose stress. Previously we have identified Cpc2 as an important factor for cross-tolerance. This study revealed that Cpc2 plays a role in the regulation of stress-induced gene expression via facilitating nucleosome remodeling.
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Report
(3 results)
Research Products
(6 results)