Exploration of Golgi casein kinases
Project/Area Number |
25840031
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
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Research Institution | Chiba University |
Principal Investigator |
Ishikawa Hiroyuki 千葉大学, 理学(系)研究科(研究院), 准教授 (00398819)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | ゴルジ体キナーゼ / リン酸化 / 翻訳後修飾 / 分泌経路 |
Outline of Final Research Achievements |
Casein is a secretory phosphorylated protein containing in milk. We attempted to identify the kinase molecule to phosphorylate casein in the Golgi. As a result, we identified candidate genes for novel Golgi kinases in the Drosophila genome. We also succeeded in producing Drosophila mutants of these genes. Further, we found that overexpression of a Golgi kinase FAM20C affected the normal development of Drosophila.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster.2014
Author(s)
Nakayama M, Ishibashi T, Ishikawa HO, Sato H, Usui T, Okuda T, Yashiro H, Ishikawa H, Taikou Y, Minami A, Kato K, Taki M, Aigaki T, Gunji W, Ohtsu M, Murakami Y, Tanuma SI, Tsuboi A, Adachi M, Kuroda J, Sasamura T, Yamakawa T, Matsuno K.
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Journal Title
BMC Genet
Volume: 15
Pages: 46-46
Related Report
Peer Reviewed
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