| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, I examined to reveal the role of polymerized osteopontin (catalyzed by protein-crosslink enzyme, transglutaminase 2) on inflammation. As a result, it was cleared that osteopontin and transglutaminase 2 were up-regulated by pro-inflammatry cytokine, TGF-β1 and the former was polymerized on cell membrane fraction by the latter. I was also successful in the generation on transgenic mice expressed polymerization-incompetent mutant osteopontin specific in lung.
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