The role of polymeric osteopontin on inflammation
| Project/Area Number |
25840034
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 生理活性物質 / オステオポンチン / 重合 / 炎症 |
|---|
| Outline of Final Research Achievements |
In this study, I examined to reveal the role of polymerized osteopontin (catalyzed by protein-crosslink enzyme, transglutaminase 2) on inflammation. As a result, it was cleared that osteopontin and transglutaminase 2 were up-regulated by pro-inflammatry cytokine, TGF-β1 and the former was polymerized on cell membrane fraction by the latter. I was also successful in the generation on transgenic mice expressed polymerization-incompetent mutant osteopontin specific in lung.
|
Report
(3 results)
Research Products
(7 results)
