Analysis of regulatory mechanisms in torque generation of the bacterial flagellar motor
| Project/Area Number |
25840054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Hosei University |
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Principal Investigator |
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| Research Collaborator |
KAWAGISHI Ikuro 法政大学, 生命科学部, 教授 (80234037)
YAMAMOTO Kaneyoshi 法政大学, 生命科学部, 教授 (40351580)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 細菌べん毛モーター / 分子モーター |
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| Outline of Final Research Achievements |
In this research, we aimed to reveal regulatory mechanisms in torque generation of the bacterial flagellar motor at single molecule level. We have demonstrated that a genetically engineered hybrid-fuel flagellar motor in Escherichia coli that runs on both types of ion gradient, protons and sodium ions, although natural E. coli cells have only proton-driven one. We also found that the hybrid motors regulate the generated torque automatically and dynamically in response to external conditions, by swapping the motor components.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Populational Heterogeneity vs. Temporal Fluctuation in Escherichia coli Flagellar Motor Switching.2013
Author(s)
Bai, F., Che, Y-S., Kami-ike, N., Ma, Q., Minamino, T., Sowa, Y. & Namba, K.
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Journal Title
Biophys. J.
Volume: 105
Issue: 9
Pages: 2123-2129
DOI
Related Report
Peer Reviewed
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