| Project/Area Number |
25840070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
UEHARA Ryota 北海道大学, 創成研究機構, 特任助教 (20580020)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 細胞質分裂 / 微小管 / アクチン / 細胞分裂 / 細胞骨格 / 中央紡錘体 |
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| Outline of Final Research Achievements |
Precise control of cell division is essential for securing biological processes of heredity and homeostasis. However, molecular mechanisms of spatiotemporal regulation of cell division remain largely unknown. In this project, we looked into microtubule dynamics during cell division phase in human cultured cells, and aimed to elucidate their contributions to the determination of division sites within dividing cells. We found that Kif2A, a microtubule depolymerizing protein plays a pivotal role in microtubule length control within the central spindle, which segregates the two masses of the sister chromosomes in an appropriate distance. We also found that augmin, a regulator of central spindle microtubule generation mediates accumulation of cytokinesis regulators to the equatorial cortex, which is essential for efficient furrow ingression. Our results shed light on new mechanisms of cell division control through dynamic reorganizations of microtubules during cytokinesis.
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