Analysis on the autophagic membrane biogenesis using imaging tools
| Project/Area Number |
25840075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
HAMASAKI Maho 大阪大学, 生命機能研究科, 准教授 (30455216)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | オートファジー / 分解 / 膜輸送 / 小胞体 / CLEM / MAM / ミトコンドリア / メンブレントラフィック / オルガネラ |
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| Outline of Final Research Achievements |
Autophagy is an one of the major degradation system in the cell, triggered under starved condition to survive and also involved in many different type of diseases such as cancer, neurodegenerative disease, life style disease and so on. When autophagy is induced, membrane structure called autopahgosomes are formed and their formation takes place at ER-mitochondria contact sites. Many autophagy related genes are identified, however, still detail mechanism on how the membrane formation takes place is unknown. By using up-to-date imaging tools including light and electron microscopy, further characterization was performed.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury2013
Author(s)
Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T
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Journal Title
EMBO J.
Volume: 32
Issue: 17
Pages: 2336-47
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Autophagosomes form at ER.mitochondria contact sites2013
Author(s)
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
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Journal Title
Nature
Volume: 495
Issue: 7441
Pages: 389-93
DOI
Related Report
Peer Reviewed
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[Journal Article] Critical roles for lipomannan and lipoarabinomannan in cell wall integrity of mycobacteria and pathogenesis of tuberculosis.2013
Author(s)
Fukuda T, Matsumura T, Ato M, Hamasaki M, Nishiuchi Y, Murakami Y, Maeda Y, Yoshimori T, Matsumoto S, Kobayashi K, Kinoshita T, Morita Y.
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Journal Title
DOI
Related Report
Peer Reviewed
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