ERdj5 mediated ER homeostatic mechanism
| Project/Area Number |
25840079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
USHIODA Ryo 京都産業大学, 総合生命科学部, 助教 (30553367)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | タンパク質品質管理 / レドックス / 小胞体関連分解 / カルシウム恒常性 / 小胞体品質管理 / レドックス制御 / カルシウムホメオスタシス |
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| Outline of Final Research Achievements |
We declared that ERdj5 interacts with SERCA2, which is a Ca2+ uptake pump, through the mixed disulfide bond. It suggests that ERdj5 reductase activity promotes SERCA2 pump function. Recently, we found the oligomer formation of ERdj5 depending on Ca2+ concentration in ER. These oligomer formation regulates the interaction with SERCA2. Additionally, we reported that accumulations of collagen by Hsp47 deficient lead to Cell death through ER stress by Autophagy inhibition. Especially, these cell death links to therapeutic for liver fibrosis (K. Kawasaki, R.Ushioda et al. 2015 J. Biol. Chem.)
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum2015
Author(s)
Avezov E, Konno T, Zyryanova A, Chen W, Laine R, Crespillo-Casado A, Melo E, Ushioda R, Nagata K, Kaminski CF, Harding HP, Ron D
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Journal Title
BMC Biol.
Volume: 13(1):2
Issue: 1
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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