| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
To understand the generality and diversity of the molecular mechanisms which regulate the function of germline cells among species, we performed functional analyses of genes using mice and Drosophila. In Drosophila, Ca2+-dependent phosphatase calcineurin and glycogen synthase kinase-3 (GSK-3) play essential roles in meiotic progression upon egg activation. We found that in mice these molecules are involved in sperm-oocyte fusion and block to polyspermy. In addition, we demonstrated the first evidence for a wave of increased Ca2+ during egg activation in Drosophila.
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