Mechanism to maintain pluripotency of the mouse epiblast via Nodal signaling.
| Project/Area Number |
25840087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kyushu University |
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Principal Investigator |
Oki Shinya 九州大学, 医学(系)研究科(研究院), 助教 (90452713)
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| Co-Investigator(Renkei-kenkyūsha) |
MENO Chikara 九州大学, 大学院医学研究院, 教授 (20311764)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | Nodal / エピブラスト / 中胚葉誘導 / 原条形成 / 多分化能 / ChIP-seq |
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| Outline of Final Research Achievements |
This study identified the genes directly regulated by Nodal signaling in the mouse epiblast, particularly involved in the pluripotency, differentiation into the neural epithelium, and primitive streak formation. This study also developed a software and database that are useful to exploit published ChIP-seq data.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.2015
Author(s)
Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
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Journal Title
J Cell Biochem
Volume: 117
Issue: 3
Pages: 780-792
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Self-regulated left-right asymmetric expression of Pitx2c in the developing limb2014
Author(s)
Shiratori, H., Yashiro, Iwai, N., Oki, S., Ikawa, Y., Kanata, K., and Hamada, H.
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Journal Title
Dev. Biol.
Volume: 395
Issue: 2
Pages: 331-341
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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