| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Apoptosis is a controlled cell death and a key process to eliminate malfunctioning and/or damaged cell for maintaining tissue homeostasis. Interestingly, the sensitivities to the stress-inducible apoptosis vary in different tissue. The sensitivities to the apoptosis is considered to be due to the acquisition of resistances to apoptosis. However, there are little studies that evidently demonstrates the physiological resistances to apoptosis in animal tissues. Here, we examined the physiological resistances to apoptosis in Drosophila tissues, male accessory gland, larval fat body and adult hindgut. In the results, we found that suppressed transcription of Dcp-1, an effector Caspase, was associated with resistances to apoptosis commonly in male accessory gland, larval fat body and adult hindgut. We also found that the hindgut additionally acquired some kind of suppression control downstream of effector Caspases.
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