The analysis of the molecular function of ROS signaling in neuroeplthelium development
Project/Area Number |
25840090
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
|
Research Institution | Doshisha University |
Principal Investigator |
Sakai Daisuke 同志社大学, 研究開発推進機構, 助教 (90632646)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 活性酸素種 / 脳発生 / 活性酸素 / 胚発生 / 呼吸代謝 / 活性酸素シグナル / 脳原基形成異常 |
Outline of Final Research Achievements |
In this study, I investigated whether reactive oxygen species (ROS) function as signaling molecule on embryonic brain development. Consequently, I revealed that ROS were required for proliferation of neural progenitor cells and consequent neurogenesis. Furthermore, ROS were involved in cranial neural crest development. Tissue specific ROS generation appeared to be dependent on the activity of cellular metabolism, glycolysis, but independent on ROS-generating NADPH oxidases.
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Report
(4 results)
Research Products
(8 results)