Elucidation of mechanisms that establish boundaries of dendritic fields in sensory neurons
| Project/Area Number |
25840094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo (2014)
公益財団法人大阪バイオサイエンス研究所 (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 受容野境界 / Wnt5 / Ryk / drl / 神経ー表皮間相互作用 / in vivo イメージング / 感覚神経 / ショウジョウバエ / Wnt / 受容野 / 樹状突起 / ライブイメージング / in vivo / RhoGEF / サイズ / 神経表皮間相互作用 |
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| Outline of Final Research Achievements |
In this study, we investigated molecular and cellular mechanisms by which boundaries of dendritic fields were established in Drosophila sensory neurons. Using a combination of in vivo imaging techniques and molecular genetics, we found that Wnt5 protein prevented dendritic branches from growing across the boundary during the dendrite development.
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Report
(3 results)
Research Products
(6 results)
