Study on functional evolution of the digestive hormone peptide cholecystokinin(CCK)/gastrin: Expression analysis of CCK/gastrin peptide in ascidian Ciona intestinalis
Project/Area Number |
25840114
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
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Research Institution | Kanazawa University |
Principal Investigator |
TOSHIO Sekiguchi 金沢大学, 環日本海域環境研究センター, 助教 (40378568)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | コレシストキニン / ガストリン / カタユウレイボヤ / Cholecystokinin / gastrin / ciona intestinalis / cionin |
Outline of Final Research Achievements |
To elucidate the evolution of the digestive hormone cholecystokinin (CCK)/gastrin in chordates, we analyzed the expression of cionin which is a CCK/gastrin ortholog and cionin receptor in the ascidian Ciona intestinalis. Analysis of cionin receptor gene promoter-driven fluorescence demonstrated that the cionin receptor was expressed in the visceral ganglion and tail nerve cord of larval ascidians. This expression pattern coincided with cholinergic neurons. In adult ascidians, cionin mRNA was exclusively expressed in the central nervous system, whereas the expression of cionin receptor mRNA was detected in both the central nervous system and digestive tract. These results suggest that cionin is released from the central nervous system and acts as a neurotransmitter or neuromodulator, affecting cionin receptor-expressing neurons. Alternatively, cionin can affect the digestive tract as a digestive hormone.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Effects of inorganic mercury and methylmercury on osteoclasts and osteoblasts in the scales of the marine teleost as a model system of bone2014
Author(s)
Yachiguchi K, Sekiguchi T, Nakano M, Hattori A, Yamamoto M, Kitamura K, Maeda M, Tabuchi Y, Kondo T, Kamauchi H, Nakabayashi H, Srivastav AK, Hayakawa K, Sakamoto T, Suzuki N
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Journal Title
Zoolog Sci
Volume: 31
Issue: 5
Pages: 330-337
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Increased PGE2 has a positive correlation with plasma calcium during goldfish reproduction.2014
Author(s)
Suzuki, N., Maruyama, Y., Nakano, M., Hattori, A., Honda, M., Shimazaki, Y., Sekiguchi, T., Kamauchi, H., Mishima, H., Wada, S., Srivastav, A.K., Hayakawa, K. and Oshima, Y.
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Journal Title
J. Fac. Agr., Kyushu Univ.
Volume: 59
Pages: 97-101
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Accumulation of organotins in wharf roach (Ligia exotica Roux) and its ability to serve as a biomonitoring species for coastal pollution2013
Author(s)
Undap S.L., Matsunaga, S., Honda, M., Sekiguchi, T., Suzuki, N., Khalil, F., Qiu, X., Shimasaki, Y., Ando, H., Sato-Okoshi, W., Sunobe, T., Takeda, S., Munehara, H., Oshima, Y.
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Journal Title
Ecotoxicology and Environmental Safety
Volume: 96
Pages: 75-79
DOI
Related Report
Peer Reviewed
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[Journal Article] Polychlorinated biphenyl (118) activates osteoclasts and induces bone resorption in goldfish.2012
Author(s)
Yachiguchi, K., Matsumoto, N., Haga, Y., Suzuki, M., Matsumura, C., Tsurukawa, M., Okuno, T., Nakano, T., Kawabe, K., Kitamura, K., et al.
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Journal Title
Env. Sci. Poll. Res.
Volume: 12
Issue: 10
Pages: 1347-1355
DOI
NAID
Related Report
Peer Reviewed / Open Access
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