| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Hypothalamus-pituitary-thyroid gland (HPT) axis plays an important role to maintain body temperature in mammals. Thyrotropin-releasing factor (TRH) is a major factor that enhances the release of thyroid-stimulating hormone (TSH) from the pituitary in mammals, whereas it mainly acts as a prolactin-releasing factor in amphibians. In this study, it was revealed that expression of TRH precursor mRNA in the frog hypothalamus was increased by cold stimulation as in mammals. The discrepancy in the role of hypothalamic factors between amphibians and mammals is discussed in relation to metamorphosis and thermoregulation.
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