Elucidation of the signaling cascades in ovarian follicle growth by tachykinin-induced prostaglandins
| Project/Area Number |
25840117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Nara Women's University |
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Principal Investigator |
AOYAMA Masato 奈良女子大学, 理学部, 非常勤研究員 (60634813)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 比較内分泌 / 卵胞成長 / マウス / タキキニン / プロスタグランジン |
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| Outline of Final Research Achievements |
We verified that a neuropeptide, tachykinin (TK), up-regulates multiple signaling pathways responsible for gene expression of prostaglandin H synthase (Cox-2) in the 2-week old mouse ovaries. Moreover, we revealed that activation of several prostaglandin receptors is involved in the growth of mouse secondary follicles. These results suggest that activation of the TK/Cox-2/prostaglandin pathway up-regulates the growth of secondary follicles that are gonadotropin-independent in the 2-weeks old mouse ovaries.
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Report
(3 results)
Research Products
(2 results)
