| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The localization of spermatogenic protein, Argonaute 2 (Ago2) function to interfer the transcription was identified on the rat testis. Ago2 was localized germ cell specific organelle, “Nuage” during the development on spermatocyte to spermatid. Moreover, the co-localization of Ago2 and lysosome membrane protein, LAMP2 in the clear vesicles surrounded on the Chromatoid body was identified by the Immunoelectron microscopic analysis in the late stage of spermatid. These results suggest that not only Ago2 modulate transcription of RNA in nuage structure but also related on the lysosome pathway in the late CB.
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