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Functional analysis of putative output factors of the insect circadian clock.

Research Project

Project/Area Number 25840121
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Animal physiology/Animal behavior
Research InstitutionOkayama University

Principal Investigator

YOSHII Taishi  岡山大学, 自然科学研究科, 准教授 (50611357)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords概日時計 / 体内時計 / キイロショウジョウバエ / 時間生物学 / 時計細胞 / 神経ペプチド / RNA干渉 / RNA干渉法
Outline of Final Research Achievements

In Drosophila melanogaster, the molecular mechanism of circadian clock has been well investigated. However, its neuronal mechanism still remains elusive. The Drosophila brain contains about 150 neurons that are responsible for circadian rhythms in behavior. The motivation of this study is to understand how the circadian clock neurons read out time information, which they generate, to downstream neurons. Here, we found that ITP and CCHa1 are new candidate peptides that function as output factors of the clock neurons.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Cryptochrome-dependent and -independent circadian entrainment circuits in Drosophila.2015

    • Author(s)
      Yoshii T, Hermann-Luibl C, Kistenpfennig C, Schmid B, Tomioka K, Helfrich-Foerster C
    • Journal Title

      Journal of Neuroscience

      Volume: 35 Issue: 15 Pages: 6131-6141

    • DOI

      10.1523/jneurosci.0070-15.2015

    • NAID

      120005702488

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Moonlight detection by Drosophila's endogenous clock depends on multiple photopigments in the compound eyes.2014

    • Author(s)
      Schlichting M, Grebler R, Peschel N, Yoshii T, Helfrich-Foerster C
    • Journal Title

      Journal of Biological Rhythms

      Volume: 29 Issue: 2 Pages: 75-86

    • DOI

      10.1177/0748730413520428

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Ion Transport Peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster.2014

    • Author(s)
      Hermann-Luibl C, Yoshii T, Senthilan PR, Dircksen H, Helfrich-Foerster C
    • Journal Title

      Journal of Neuroscience

      Volume: 34 Issue: 29 Pages: 9522-9536

    • DOI

      10.1523/jneurosci.0111-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The MAP Kinase p38 is part of Drosophila's circadian clock.2014

    • Author(s)
      Dusik V, Senthilan PR, Menzel B, Hartlieb H, Wuelbeck C, Yoshii T, Raabe T, Helfrich-Foerster C
    • Journal Title

      PLOS Genetics

      Volume: 10 Issue: 8 Pages: e1004565-e1004565

    • DOI

      10.1371/journal.pgen.1004565

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sexual interactions influence the molecular oscillations in DN1 pacemaker neurons in Drosophila melanogaster2013

    • Author(s)
      Hanafusa S., Kawaguchi T., Umezaki Y., Tomioka K., Yoshii T
    • Journal Title

      PLoS ONE

      Volume: 8(12) Issue: 12 Pages: e84495-e84495

    • DOI

      10.1371/journal.pone.0084495

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long・term effect of systemic RNA interference on circadian clock genes in hemimetabolous insects.2013

    • Author(s)
      瓜生央大
    • Journal Title

      Journal of Insect Physiology

      Volume: 59(4) Issue: 4 Pages: 494-499

    • DOI

      10.1016/j.jinsphys.2013.02.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] GABAB receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster.2013

    • Author(s)
      Gmeiner F, Kołodziejczyk A, Yoshii T, Rieger D, Nässel DR, Helfrich-Förster C
    • Journal Title

      The Journal of Experimental Biology

      Volume: 216 Issue: 20 Pages: 3827-3843

    • DOI

      10.1242/jeb.085563

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exquisite Light Sensitivity of Drosophila Cryptochrome.2013

    • Author(s)
      Vinayak P, Coupar J, Hughes SE, Fozdar P, Kilby J, Garren E, Yoshii T, Hirsh J
    • Journal Title

      PLOS Genetics

      Volume: 9 Issue: 7 Pages: e1003615-e1003615

    • DOI

      10.1371/journal.pgen.1003615

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ITP神経ペプチドはキイロショウジョウバエ概日時計の新規出力因子2014

    • Author(s)
      吉井大志, C. Hermann-Luibl, C. Helfrich-Foerster
    • Organizer
      第85回日本動物学会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] CRY expression in a subset of Drosophila clock neurons2014

    • Author(s)
      Taishi Yoshii
    • Organizer
      SRBR 2014 Society for Research on Biological rhythms
    • Place of Presentation
      Big Sky, Montana, USA
    • Year and Date
      2014-06-14 – 2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] キイロショウジョウバエ概日時計のCRY依存的な光同調神経機構2013

    • Author(s)
      吉井大志, C. Kistenpfennig, 富岡憲治
    • Organizer
      日本動物学会
    • Place of Presentation
      岡山県、岡山市
    • Related Report
      2013 Research-status Report
  • [Presentation] Circadian neural networks for Cryptochrome-dependent light-entrainment in Drosophila melanogaster2013

    • Author(s)
      T. Yoshii, C. Kistenpfennig, C. Helfrich-Förster, K. Tomioka
    • Organizer
      XIII Congress EBRS
    • Place of Presentation
      Munich, Germany
    • Related Report
      2013 Research-status Report
  • [Book] 天体航法,環境Eco選書 昆虫の時計―分子から野外まで―,沼田英治編2014

    • Author(s)
      吉井大志
    • Total Pages
      32
    • Publisher
      北隆館
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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