| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
High alcoholic fermentation performance of sake yeast strains is attributed to a loss-of-function mutation in the RIM15 protein kinase gene. In this study, we examined its effects on the intracellular metabolic profile and the gene expression, and found that impairment of the synthetic pathway of UDP-glucose leads to enhanced glycolysis/alcoholic fermentation. Thus, we first discovered a sake yeast-specific high fermentation mechanism. Furthermore, dysfunction of the RIM15 gene effectively improved the fermentation rates of the other industrial yeast strains. Our finding will aid in establishing a novel breeding technology for the artificial control of alcoholic fermentation performance by yeast cells.
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