| Project/Area Number |
25850066
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied biochemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SAWANO Yoriko 東京医科歯科大学, 教養部, 准教授 (00571077)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 植物ホルモン / アブシジン酸 / 乾燥ストレス耐性 / 分子改変 / 相互作用解析 / 立体構造解析 |
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| Outline of Final Research Achievements |
The signaling pathway related to a plant hormone, abscisic acid (ABA), plays a major role on the acquiring mechanism of resistance to drought in plants. This study was clarified the combinations to form a secondary or a ternary complex by analysis of interactions with key regulatory proteins in ABA signaling pathway, namely ABA receptors PYR/PYL, protein kinases SnRK2s known as positive regulators, and protein phosphatases PP2Cs known as negative regulators, and crystallization experiments on the target single protein and the protein complex were conducted for structural analysis. These findings are expected to provide novel information on the molecular alteration towards breeding of drought tolerance plants.
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