A study on the food development for the prevention of tumor angiogenesis

• Project/Area Number: 25850086
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: TSUDUKI Tsuyoshi 東北大学, (連合)農学研究科(研究院), 准教授 (00404848)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 血管新生 / リノレン酸 / エレオステアリン酸 / 共役リノレン酸 / 共役リノール酸 / キリ / ニガウリ / がん / 共役脂肪酸 / 脂肪酸 / マウス / 血管内皮細胞 / 共役EPA / 共役DHA

Outline of Final Research Achievements

In the current study, the antiangiogenic effects of ESA were investigated in vitro. ESA also inhibited the formation of capillary-like networks by human umbilical vein endothelial cells (HUVEC) and moderately inhibited HUVEC proliferation and migration in a dose-dependent manner. The mechanism by which ESA inhibited angiogenesis was through activation of peroxisome proliferator-activated receptor (PPAR) γ and induction of apoptosis in HUVEC. We thus demonstrated that, like troglitazone, ESA is a PPARγ ligand, and that it activates PPARγ induces apoptosis in HUVEC, and inhibits angiogenesis. Our findings suggest that ESA has potential use as a therapeutic dietary supplement and medicine for minimizing tumor angiogenesis.

Research Products

• [Journal Article] Research on food and nutrition characteristics of conjugated fatty acids. (2015)
  • Author(s): T. Tsuduki
  • Journal Title: Biosci Biotechnol Biochem. Volume: 30 Pages: 1-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Decreased lipid absorption due to reduced pancreatic lipase activity in aging male mice. (2014)
  • Author(s): K. Yamamoto, Y. Kitano, S. E, Y. Hatakeyama, Y. Sakamoto, T. Honma, T. Tsuduki.
  • Journal Title: Biogerontology Volume: 15 Issue: 5 Pages: 463-473
  • DOI: 10.1007/s10522-014-9512-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 1-deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells (2014)
  • Author(s): E, S., Kijima, R., Honma, T., Yamamoto, K., Hatakeyama, Y., Kitano, Y., Kimura, T., Nakagawa, K., Miyazawa, T., Tsuduki, T.
  • Journal Title: Exp. Gerontol. Volume: 55C Pages: 63-69
  • DOI: 10.1016/j.exger.2014.03.025
  • Peer Reviewed / Open Access
• [Presentation] 天然由来機能性脂質の食品栄養学的特性に関する研究 (2014)
  • Author(s): 都築 毅
  • Organizer: 日本農芸化学会東北支部特別シンポジウム
  • Place of Presentation: 東北大学（仙台）
  • Year and Date: 2014-11-29
  • Invited
• [Remarks] 都築研究室
  • URL: http://tsuduki.sakura.ne.jp/index.html