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Search of Co-solvents of Poorly Water-soluble Bioactive Compounds in Natural Products on the Basis of the Accurate Solubility Measurements

Research Project

Project/Area Number 25850094
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionNihon University

Principal Investigator

MATSUDA Hiroyuki  日本大学, 理工学部, 准教授 (50339256)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords生体活性成分 / クルクミン / 助可溶化剤 / 溶解性向上 / 難水溶性 / 溶解度向上 / 包接化合物 / シクロデキストリン
Outline of Final Research Achievements

We selected curcumin as poorly water-soluble bio-active compound which is contained in curry powder. We used several β-CD derivatives as co-solvent of curcumin, and enhancement of solubility in water was evaluated by measuring solubilities. These solubility data would be useful for a development of functional foods that efficient absorption of poorly water-soluble bio-active compound is available.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Measurement and Correlation of Solubilities of Poorly Water-soluble Pharmaceutical Compound Etodolac by Addition of Co-solvents2015

    • Author(s)
      Hiroyuki Matsuda, Kanako Mori, Mariko Tomioka, Nozomi Kariyasu, Toshiro Fukami, Kiyofumi Kurihara, Katsumi Tochigi, and Kazuo Tomono
    • Journal Title

      Fluid Phase Equilibria

      Volume: 406 Pages: 116-123

    • DOI

      10.1016/j.fluid.2015.07.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Search of Co-solvents of Poorly Water-soluble Bioactive Compounds in Natural Products on the Basis of the Solubility Measurements2016

    • Author(s)
      Hiroyuki Matsuda, Kiyofumi Kurihara, Katsumi Tochigi, and Kazuo Tomono
    • Organizer
      2nd International Conference and Expo on Biopharmaceutics
    • Place of Presentation
      アメリカ・サンアントニオ
    • Year and Date
      2016-09-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 医薬品製造プロセスにおける溶解度の重要性 -溶解度-2015

    • Author(s)
      松田弘幸
    • Organizer
      分離技術会講習会「医薬品・粒子製造プロセスにおける操作の実践」
    • Place of Presentation
      日本大学理工学部(東京都千代田区)
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Search of Co-solvents of Poorly Water-Soluble Bioactive Compounds in Natural Products on the Basis of the Solubility Measurements2015

    • Author(s)
      Hiroyuki Matsuda, Mami Ozawa, Kiyofumi Kurihara, Katsumi Tochigi, and Kazuo Tomono
    • Organizer
      6th International Symposium on Solubility Phenomena and Related Equilibrium Processes
    • Place of Presentation
      ドイツ・カールスルーエ
    • Year and Date
      2015-07-21 – 2015-07-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Synthetic法を用いた医薬品の溶解度の測定ならびに1-オクタノール/水分配係数の決定2015

    • Author(s)
      松田弘幸,山口祐美,浮谷基彦,栗原清文,栃木勝己
    • Organizer
      分離技術会年会2015
    • Place of Presentation
      明治大学生田キャンパス(神奈川県川崎市多摩区)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Determination of Co-solvent Effect of Poorly Water-Soluble Pharmaceuticals by Addition of Cyclodextrins2013

    • Author(s)
      H. Matsuda, Y. Naito, A. Sakai, K. Kurihara, K. Tochigi, K. Tomono
    • Organizer
      3rd European Conference on Cyclodextrins
    • Place of Presentation
      トルコ・アンタルヤ
    • Related Report
      2013 Research-status Report
  • [Book] 化学工学物性測定マニュアル2015

    • Author(s)
      岩井芳夫,滝嶌繁樹,辻智也,栃木勝己(編著)
    • Total Pages
      191
    • Publisher
      化学工業社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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