| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Adiponectin is a protein that is mainly secreted from adipocytes and exhibits an antidiabetic property, which enhances insulin action. Our previous studies showed that protein malnutrition caused increases in circulating adiponectin levels in growing rats. In this study, we found that the enhancement of adiponectin secretion from adipocytes and/or the suppression of its degradation in the blood result in the elevation of circulating adiponectin levels in protein-malnourished rats. Furthermore, it was suggested that lower circulating insulin and insulin-like growth factor-1 contribute to enhance adiponectin secretion from adipocytes under protein malnutrition.
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