Anti-allergic effects of seaweed polyphenols, namely phlorotannin, from edible brown algae which is little-used.
Project/Area Number |
25850099
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | National Fisheries University |
Principal Investigator |
Sugiura Yoshimasa 独立行政法人水産大学校, その他部局等, 准教授 (60608107)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 褐藻 / アレルギー / 生理活性 / 食品機能 / 水産化学 / 低利用食用褐藻類 / 抗アレルギー効果 / 抗炎症効果 / フロロタンニン |
Outline of Final Research Achievements |
From a lipophilic fraction of Eisenia arborea extract, bis(2-ethylhexyl) phthalate was isolated and idetified as an active compound. Four brown algal extracts and 2 purified phlorotannins had permeated Caco-2 cells, and the permeation ratios were 3-17 % and about 30 %, respectively. Condenced phlorotannin (Pt) excerted anti-allergic effect on pollen allergy and food allergy model mice. The mechanism would attribute to immunomodulating activity of Pt. To investigate anti-degranulation effect of Pt on mast cells, the effect of it on expression of protein kinase Cα (PKCα) in RBL-2H3 cells was measured by western blot method. But, the suppression of Pt on PKCα protein expression was not observed. Moerover, in vivo and in vitro experiments, fucoxanthin that is a marine carotenoid indicated anti-allergic effects.
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Report
(4 results)
Research Products
(13 results)