| Project/Area Number |
25850131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Aquatic bioproduction science
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| Research Institution | Fisheries Research Agency |
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Principal Investigator |
HANO Takeshi 独立行政法人水産総合研究センター, 瀬戸内海区水産研究所, 研究員 (30621057)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Katsutoshi 国立研究開発法人・水産総合研究センター, 瀬戸内海区水産研究所, 主任研究員 (80450782)
KONO Kumiko 国立研究開発法人・水産総合研究センター, 瀬戸内海区水産研究所, 主任研究員 (10371973)
ITO Mana 国立研究開発法人・水産総合研究センター, 瀬戸内海区水産研究所, 任期付研究員 (60735900)
OHKUBO Nobuyuki 国立研究開発法人・水産総合研究センター, 瀬戸内海区水産研究所, 主任研究員 (50371787)
MOCHIDA Kazuhiko
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | タウリン / メタボローム解析 / 肝機能 / 解毒排泄 / 有害化学物質 / 養殖 / 食の安全 / 肝臓 / フェナントレン / 毒性軽減 / 排泄促進 / 薬物代謝酵素 / カドミウム / 代謝物総体解析 |
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| Outline of Final Research Achievements |
In this study, we carried out to examine the ameliorative effects of taurine administration against two harmful chemical substances (e.g. cadmium, a toxic metal, and phenanthrene, one of polycyclic aromatic hydrocarbons) and to elucidate underlying possible mechanisms in marine teleost aquaculture fish, Pagrus major. First, we found that appropriate levels of taurine administration could reduce the chemical-induced mortality by 1/13-1/10 and inhibit bioaccumulation of cadmium in the liver. These phenomena are partly explained by imbalanced metabolite profile in the liver by taurine deficiency such as amino acids and sugar alcohols. In summary, the present findings demonstrates that taurine is an essential nutrient for marine teleost fish in terms of alleviation of adverse effect caused by harmful chemical substances and plays a promising role in human consumption and welfare.
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