Studies of oncogenesis and viral pathogenesis of Oncorhunchus masou virus (OMV; Salmonid herpesvirus 2) in salmonid fish
| Project/Area Number |
25850132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Aquatic bioproduction science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kasai Hisae 北海道大学, 水産科学研究科(研究院), 准教授 (50399995)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | OMV / 魚類ウイルス / ヘルペスウイルス / 腫瘍 |
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| Outline of Final Research Achievements |
Oncorhynchus masou virus (OMV; Salmonid herpesvirus 2) is a member of Herpisviridae associated with oncogenic and hepatitic diseases of national and international socio-economic importance. The present study focused on oncogenesis and viral pathogenesis of OMV in salmonid fish. Viral genes were localized in the whole Tumor tissues of masu salmon Oncorhynchus masou that survived OMV infections. A strong ISH signal was detected in the tumor tissue indicating that OMV induces tumor development. Highly expressed viral genes in Tumor were found by transcriptome analysis using NGS-based RNA sequencing. Liver failure as well as renal dysfunction and failure of gill function were occurred in OMV-infected rainbow trout O. mykiss.
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Report
(4 results)
Research Products
(6 results)
