A study of intestinal absorption mechanism of tetrodotoxin.
| Project/Area Number |
25850144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Aquatic life science
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| Research Institution | Prefectural University of Hiroshima |
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Principal Investigator |
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| Research Collaborator |
ISHIZAKI YUI 県立広島大学, 生命環境学部, 学部生
MOCHIZUKI KEIKA 県立広島大学, 生命環境学部, 学部生
YASUI KANA 県立広島大学, 生命環境学部, 学部生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | フグ / テトロドトキシン / 食中毒 / 消化管吸収 / Caco-2細胞 / トランスポーター / 食品衛生 / ABCトランスポーター / BCRP / MRP1 / MRP2 / MDR1 |
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| Outline of Final Research Achievements |
Puffer fish contains a powerful neurotoxin, tetrodotoxin (TTX) in liver, ovary, and skin. Puffer fish poisoning develops after the ingestion of these toxic tissues. Today, puffer fish poisoning occurs annually in Japan and many other countries and regions. This study examined the transport of TTX in human intestinal Caco-2 cell monolayers, and revealed that the transport of TTX across Caco-2 cell monolayers was achieved by transcellular transport pathway. Transport inhibition assay suggested that the transport of TTX was mediated by organic ion transporters. Identification of transporters that mediate intestinal absorption of TTX merit further research.
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Report
(4 results)
Research Products
(4 results)
